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leuS [2019-08-09 07:45:56]
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leuS [2019-08-09 07:45:56]

Leu-tRNA synthetase
Locus
BSU_30320
Isoelectric point
4.86
Molecular weight
91.35 kDa
Protein length
804 aa Sequence Blast
Gene length
2415 bp Sequence Blast
Function
translation
Product
leucyl-tRNA synthetase
Essential
yes
E.C.
6.1.1.4
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Protein synthesis, modification and degradation → Translation → Aminoacyl-tRNA synthetases
  • Groups of genes → Essential genes

    • Gene

    Coordinates
    3,102,629 → 3,105,043

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu) (according to Swiss-Prot)

    • Protein family

  • Class-I aminoacyl-tRNA synthetase family (according to UniProt)

    • Structure

  • 2AJG (from Escherichia coli, 39% identity, 56% similarity) PubMed

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    leuS
    Description
    PubMed

    Regulatory mechanism

  • T-box: transcription antitermination, via uncharged tRNA-Leu binding to RNA switch, in T-box

    • Regulation

  • induced by leucine limitation (T-box) PubMed
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    References

    Reviews

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    Original Publications

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